The series was created by Craig McCracken, who had also created The Powerpuff Girls for Cartoon Network Studios. Herriman, the strict rule-abider and business manager and her granddaughter Frankie, who handles day-to-day operations. The home is run by the elderly Madame Foster, its lovable, kind founder her imaginary friend Mr.
Once children outgrow them, friends are relocated to the titular orphanage, where they stay until other children adopt them.
In the show's universe, imaginary friends take physical form and become real as soon as children think them up. The series is set in an alternate reality in which childhood imaginary friends coexist with humans.